dosage effect meaning in Hindi

Examples

1. This suggests that a gene-dosage effect might be responsible for manifestations at a younger age.
2. Gene dosage effects after duplication can also be harmful to a cell and the duplication might therefore be selected against.
3. If the duplicate copy increases the dosage effect of the gene product, then the duplicate may be retained as a redundant copy.
4. There are considerable differences between the physiology and metabolism of insects and mammals, and it is impossible to extrapolate dosage effects from insects to humans ."
5. Furthermore, Swearer, et al . ( 2010 ) discuss a " dosage effect " in which the more positive and consistent elements included in a program, the more the likelihood that bullying would decrease.
6. Gene dosage effects of extra copies of SHOX may be a cause of the increased stature seen in other sex chromosome aneuploidy conditions such as 47, XXX, 47, XYY, 47, XXY, 48, XXYY, etc.
7. It was suggested that the gene dosage effect accompanying copy number variation may lead to detrimental effects if essential cellular functions are disrupted, therefore proteins involved in cellular pathways are subjected to strong purifying selection.
8. The mechanisms leading to novel variation in newly formed allopolyploids may include gene dosage effects ( resulting from more numerous copies of genome content ), the reunion of divergent gene regulatory hierarchies, chromosomal rearrangements, and epigenetic remodeling, all of which affect gene content and / or expression levels.
9. The SHOX gene in the PAR1 region is the gene most commonly associated with and well understood with regards to disorders in humans, but all pseudoautosomal genes escape X-inactivation and are therefore candidates for having gene dosage effects in sex chromosome aneuploidy conditions ( 45, X, 47, XXX, 47, XXY, 47, XYY, etc . ).